OriginalDrugs

List of Antidepressants and Anti-Anxiety Medications

Selective serotonin reuptake inhibitors (SSRIs)

Generic name Brand names
Citalopram Celexa
Escitalopram Lexapro
Fluvoxamine maleate Luvox
Fluoxetine Prozac
Paroxetine mesylate Pexeva
Paroxetine Paxil, Paxil CR
Sertraline Zoloft

Serotonin and Norepinephrine reuptake inhibitors (SNRIs)

Generic name Brand names
Duloxetine Cymbalta
Desvenlafaxine Pristiq
Milnacipran Savella
Venlafaxine Effexor XR

Tricyclic antidepressants

Generic name Brand names
Amitriptyline Elavil
Amoxapine Asendin
Clomipramine Anafranil
Desipramine Norpramin
Doxepin Sinequan
Imipramine Tofranil
Nortriptyline Pamelor
Protriptyline Vivactil
Trimipramine Surmontil

Norepinephrine and Dopamine Reuptake Inhibitors (NDRIs)

Generic name Brand names
Bupropion Wellbutrin, Wellbutrin SR,
Wellbutrin XL, Budeprion XL

Serotonin Antagonist /Reuptake Inhibitors (SARI)

Generic name Brand names
Trazodone Oleptro
Etoperidone Axiomin, Centren, Depracer, Etonin, Etoran
Mepiprazole Psigodal
Nefazodone Serzone

Noradrenergic and Specific Serotonergic Antidepressants (NaSSA)

Generic name Brand names
Mirtazapine Remeron
Mianserin Tolvon
Setiptiline (licenced in Japan) Tecipul

Noradrenaline reuptake inhibitors (NRIs)

Generic name Brand names
Reboxetine Edronax
Atomoxetine Strattera
Viloxazine Vivalan

Melatonin receptor agonists

Generic name Brand names
Agomelatine Valdoxan

Monoamine Oxidase Inhibitors (MAOIs)

Generic name Brand names
Isocarboxazid Marplan
Phenelzine Nardil
Selegiline Emsam
Tranylcypromine Parnate

Anti-Anxiety Medications (Anxiolytics)

Generic name Brand names
Azapirones
Buspirone BuSpar
Gepirone Gepirone ER
Tandospirone Sediel
Benzodiazepines
Alprazolam Xanax
Chlordiazepoxide Librium
Clonazepam Klonopin
Clorazepate Tranxene
Diazepam Valium
Lorazepam Ativan
Oxazepam Alepam, Medopam, Murelax, Noripam, Opamox, Purata, Serax
Temazepam Restoril
Tofisopam (licenced in Japan, Europe) Emandaxin, Grandaxin
Antihistamines
Hydroxyzine Atarax, Tranquizine; Paxistil, Vistaril

Over-the-counter anti-anxiety medicines

  • OTC antihistamines Chlorpheniramine (Chlor-Trimeton) and diphenhydramine (Benadryl) have hypnotic, sedative, and mild anxiolytic properties.
  • Picamilon, a nootropic dietary supplement, combines gamma aminobutyric acid (GABA) and nicotinic acid (niacin, Vitamin B3). In animals studies Picamilon has been shown to improve cerebral circulation, and also work as tranquilizer with a stimulating component.
  • Melatonin has anxiolytic properties, likely mediated by the benzodiazepine/GABAergic system.
  • Herbal preparations: valerian, kava, chamomile.

References

  • 1. Matheson GK, Pfeifer DM, Weiberg MB, Michel C. The effects of azapirones on serotonin1A neurons of the dorsal raphe. Gen Pharmacol. 1994 Jul;25(4):675-83.
  • 2. Charlton BG. Safe interventions for panic, phobia and other anxiety-disorders might include over-the-counter (OTC) 'SSRI' antihistamines such as diphenhydramine and chlorpheniramine. Acta Psychiatr Scand. 2005 Oct;112(4):323

Author: OriginalDrugs Team
Last reviewed: October 27, 2012

Interesting Facts
  • Anxiolytics are also known as minor tranquilizers.
  • Beta-receptor blockers such as propranolol and atenolol, although not anxiolytics, can be used to relive the physiological r symptoms of anxiety.